Buddhism is a dharmic, non-theistic religion, a philosophy, and a system of psychology. Buddhism is also known in Sanskrit or Pali, the main ancient languages of Buddhists, as Buddha Dharma or Dhamma, which means the teachings of "the Enlightened One". Thus was called Siddhartha Gautama, hereinafter referred to as "the Buddha". The Buddha was born in Lumbini (now in Nepal), and that he died aged around 80 in Kushinagara (India). He lived in or around the fifth century BC. Buddhism spread throughout South Asia in the five centuries following the Buddha's passing, and thence into Central, Southeast and East Asia and Eastern Europe over the next two millennia.

Eventually, South Asian Buddhism became virtually extinct, except in parts of Nepal. Buddhism is usually classified into the three traditions;

Eastern and Northern Buddhism both call themselves Mahayana. Buddhism continues to attract followers worldwide and is considered a major world religion. According to one source, "World estimates for Buddhists vary between 230 and 500 million, with most around 350 million." According to one analysis, Buddhism is the fifth-largest religion in the world behind Christianity, Islam, Hinduism, and traditional Chinese religion. The monks' order (Sangha), which began during the lifetime of the Buddha in India, is amongst the oldest organizations on earth.

In Buddhism, any person who has awakened from the "sleep of ignorance" by directly realizing the true nature of reality is called a buddha. Siddhartha Gautama, the Buddha, is thus only one among other buddhas before or after him. His teachings are oriented toward the attainment of this kind of enlightenment, Bodhi, liberation, or Nirvana.

Part of the Buddha’s teachings regarding the holy life and the goal of liberation is constituted by the "The Four Noble Truths", which focus on dukkha, a term that refers to suffering or the sorrow of life. The Four Noble Truths regarding suffering state what is its nature, its cause, its cessation, and the way leading to its cessation. This way to the cessation of suffering is called "The Noble Eightfold Path", which is one of the fundamentals of Buddhist virtuous or moral life.

Greco-Buddhism, is the cultural syncretism between Hellenistic culture and Buddhism, which developed over a period of close to 800 years in the area corresponding to modern-day Afghanistan and Pakistan, between the 4th century BCE and the 5th century CE. Greco-Buddhism influenced the artistic (and, possibly, conceptual) development of Buddhism, and in particular Mahayana Buddhism, before it was adopted by Central and Northeastern Asia from the 1st century CE, ultimately spreading to China, Korea and Japan.

The interaction between Hellenistic Greece and Buddhism started when Alexander the Great conquered South in 326 BC, crossing the Indus and Jhelum rivers, and going as far as the Beas, thus establishing direct contact with India, the birthplace of Buddhism.

Alexander founded several cities in his new territories in the areas of the Oxus and Bactria, and Greek settlements further extended to the Khyber Pass, Gandhara and the Punjab. These regions correspond to a unique geographical passageway between the Himalayas and the Hindu Kush mountains, through which most of the interaction between the South and Central Asia took place, generating intense cultural exchange and trade. The interaction of Greek and Buddhist cultures operated over several centuries until it ended in the 5th century CE with the invasions of the White Huns, and later the expansion of Islam.

Pakistan, the crucible of many cultures and civilizations from the Stone Age to the British Rule, has remains of ancient civilizations scattered all over the country. However, the most popular are the Indus Valley and Gandhara Civilizations. Almost all the major museums of the world has pieces of Gandhara Art exhibited in their galleries.

Gandhara, the ancient Peshawar Valley and the cradle of Buddhist Civilizations, gave birth to the famous Gandhara Art, is first mentioned in the Rigveda, and remained one of the provinces of the Achaemenian Empire as per Darius inscription of the 6th century BC. Pushkalavati (Balahisar – Charsadda), its first capital from 6th century BC till 1st century AD, was invaded in 327 BC by Alexander of Macedonia, ruled by Mauryans, Indo-Greeks, Scythians, Parthians and Kushans who established their capital at Pushpapura or Peshawar in 1st century AD. In 7th century AD, the Shahi Dynasty established the capital at Hund, which remained their capital till the invasions of Ghaznavids in 998 AD, thus ending the rule of Gandhara.

The sites and antiquities of Takht-e-Bahi, Sahri Bahlol, Jamal Garhi, Rani Gat, Aziz Dheri, Butkara, Saidu Stupa, Andan Dheri, Chat Pat, Dam Kot, Khanpur and the monasteries in the Taxila Valley provided the richest collection of Gandhara Art to the Peshawar, Taxila, Swat, Dir and Peshawar University museums through the excavations by British, Italian and Pakistani scholars.